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Published clinical studies related to danone exclusive strains

2011

• The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins. McNulty NP, Yatsunenko T, Hsiao A, Faith JJ, Muegge BD, Goodman AL, Henrissat B, Oozeer R, Cools-Portier S, Gobert G, Chervaux C, Knights D, Lozupone CA, Knight R, Duncan AE, Bain JR, Muehlbauer MJ, Newgard CB, Heath AC, Gordon JI. Sci Transl Med. 2011 Oct 26;3(106):106ra106. PMID: 22030749 [PubMed - in process]


• Fermented milk containing Bifidobacterium lactis DN-173 010 in childhood constipation: a randomized, double-blind, controlled trial. Tabbers MM, Chmielewska A, Roseboom MG, Crastes N, Perrin C, Reitsma JB, Norbruis O, Szajewska H, Benninga MA. Pediatrics. 2011 Jun;127(6):e1392-9. Epub 2011 May 23. PMID: 21606153 [PubMed - indexed for MEDLINE]

2010

• Effects of consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 on common respiratory and gastrointestinal infections in shift workers in a randomized controlled trial. Guillemard E, Tanguy J, Flavigny A, de la Motte S, Schrezenmeir J. J Am Coll Nutr. 2010 Oct;29(5):455-68. PMID: 21504972 [PubMed - indexed for MEDLINE]
  Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study. A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial. Merenstein D, Murphy M, Fokar A, Hernandez RK, Park H, Nsouli H, Sanders ME, Davis BA, Niborski V, Tondu F, Shara NM. Eur J Clin Nutr. 2010 Jul;64(7):669-77. Epub 2010 May 19. PMID: 20485304 [PubMed - indexed for MEDLINE] Free PMC Article

2009

• Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial. Guillemard E, Tondu F, Lacoin F, Schrezenmeir J. Br J Nutr. 2010 Jan;103(1):58-68. Epub 2009 Sep 14. PMID: 19747410 [PubMed - indexed for MEDLINE]
  A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials. Boge T, Rémigy M, Vaudaine S, Tanguy J, Bourdet-Sicard R, van der Werf S. Vaccine. 2009 Sep 18;27(41):5677-84. Epub 2009 Jul 16. PMID: 19615959 [PubMed - indexed for MEDLINE]


• Fermented milk containing Bifidobacterium lactis DN-173 010 improves gastrointestinal well-being and digestive symptoms in women reporting minor digestive symptoms: a randomised, double-blind, parallel, controlled study. Guyonnet D, Schlumberger A, Mhamdi L, Jakob S, Chassany O. Br J Nutr. 2009 Dec;102(11):1654-62. Epub 2009 Jul 22. PMID: 19622191 [PubMed - indexed for MEDLINE]


• Fermented milk containing Bifidobacterium lactis DN-173 010 improved self-reported digestive comfort amongst a general population of adults. A randomized, open-label, controlled, pilot study. Guyonnet D, Woodcock A, Stefani B, Trevisan C, Hall C. J Dig Dis. 2009 Feb;10(1):61-70. PMID: 19236549 [PubMed - indexed for MEDLINE]


• Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation. Agrawal A, Houghton LA, Morris J, Reilly B, Guyonnet D, Goupil Feuillerat N, Schlumberger A, Jakob S, Whorwell PJ. Aliment Pharmacol Ther. 2009 Jan;29(1):104-14. doi: 10.1111/j.1365-2036.2008.03853.x. Epub 2008 Sep 17. PMID: 18801055 [PubMed - indexed for MEDLINE]

2008

• Effects of probiotic Lactobacillus casei DN-114 001 in prevention of radiation-induced diarrhea: results from multicenter, randomized, placebo-controlled nutritional trial. Giralt J, Regadera JP, Verges R, Romero J, de la Fuente I, Biete A, Villoria J, Cobo JM, Guarner F. Int J Radiat Oncol Biol Phys. 2008 Jul 15;71(4):1213-9. Epub 2008 Feb 19. PMID: 18243569 [PubMed - indexed for MEDLINE]


• Effect of Bifidobacterium lactis DN-173 010 on the Intestinal Transit Time, the Condition of Defecation and Intestinal Microflora: A randomized, Double-blind, Placebo-controlled, Cross-over Study among Healthy Japanese Women. Nishida S., Ishikawa Y., Iino H. Pharmacometrics 2008;74 (5/6) : 99-106.


• Survival of Bifidobacterium animalis DN-173 010 in the faecal microbiota after administration in lyophilised form or in fermented product - a randomised study in healthy adults. Rochet V, L Rigottier-Gois, A Ledaire, C Andrieux, M Sutren, S Rabot, A Mogenet, J-L Bresson, S Cools, C Picard, N Goupil-Feuillerat and J Doré. Journal of Molecular Microbiology and Biotechnology, 2008;14: 128-136.


• Effect of a fermented milk containing Bifidobacterium lactis DN-173 010 on Chinese constipated women. Yang Y., He M., Hu G., Wei J., Pages P., Yang X., Bourdu-Naturel S. World Journal of Gastroenterology, 2008; 14(40): 6237-6243.
  Immunomodulatory effects of the intake of fermented milk with Lactobacillus casei DN114001 in lactating mothers and their children. Ortiz-Andrellucchi A, Sànchez-Villegas A, Rodríguez-Gallego C, Lemes A, Molero T, Soria A, Peña-Quintana L, Santana M, Ramírez O, García J, Cabrera F, Cobo J, Serra-Majem L. Br J Nutr. 2008 Oct;100(4):834-45


• Modulation of Lactobacillus casei in ileal and fecal samples from healthy volunteers after consumption of a fermented milk containing Lactobacillus casei DN-114 001Rif Rochet V, Rigottier-Gois L, Levenez F, Cadiou J, Marteau P, Bresson JL, Goupil-Feuillerat N, Doré J. Can J Microbiol. 2008 Aug;54(8):660-7

• Effect of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects. He T, M G Priebe, Y Zhong, C Huang, HJM Harmsen, GC Raangs, JM Antoine, GW Welling and RJ Vonk. Journal of Applied Microbiology, 2008; 104(2):595-604.

2007

• A randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis. Giovannini M, Agostoni C, Riva E, Salvini F, Ruscitto A, Zuccotti GV, Radaelli G. Pediatr Res. 2007 Aug;62(2):215-20.
  Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial. Hickson M, D'Souza AL, Muthu N, Rogers TR, Want S, Rajkumar C, Bulpitt CJ. BMJ. 2007 Jul 14;335(7610):80.
  Probiotic, as well as conventional yogurt, can enhance the stimulated production of proinflammatory cytokines. Meyer AL, Elmadfa I, Herbacek I, Micksche M. J Hum Nutr Diet. 2007 Dec;20(6):590-8.


• Effect of a probiotics supplementation on respiratory infections and immune and hormonal parameters during intense military training. Tiollier E, Chennaoui M, Gomez-Merino D, Drogou C, Filaire E, Guezennec CY. Mil Med. 2007 Sep;172(9):1006-11.


• Effect of Lactobacillus casei DN-114001 application on the activity of fecal enzymes in children after liver transplantation. Pawlowska J, Klewicka E, Czubkowski P, Motyl I, Jankowska I, Libudzisz Z, Teisseyre M, Gliwicz D, Cukrowska B. Transplant Proc. 2007 Dec;39(10):3219-21.
  Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel symdrome adults in primary care. A multicentre, randomised, double-blind, controlled trial. Guyonnet D, O. Chassany, P. Ducrotte, C. Picard, M. Mouret, C.H. Mercier and C. Matuchansky. Alimentary Pharmacology and Therapeutics, 2007; 26 (3): 475-486.


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2006

• Daily intake of probiotic as well as conventional yogurt has a stimulating effect on cellular immunity in young healthy women. Meyer AL, Micksche M, Herbacek I, Elmadfa I. Ann Nutr Metab. 2006;50(3):282-9.


• Survival of Lactobacillus casei in the human digestive tract after consumption of fermented milk. Oozeer R, Leplingard A, Mater DD, Mogenet A, Michelin R, Seksek I, Marteau P, Doré J, Bresson JL, Corthier G. Appl Environ Microbiol. 2006 Aug;72(8):5615-7.



• Effects of orally administered Lactobacillus casei DN-114 001 on the composition or activities of the dominant faecal microbiota in healthy humans. Rochet V, Rigottier-Gois L, Sutren M, Krementscki MN, Andrieux C, Furet JP, Tailliez P, Levenez F, Mogenet A, Bresson JL, Méance S, Cayuela C, Leplingard A, Doré J. Br J Nutr. 2006 Feb;95(2):421-9.


• Molecular detection of Bifidobacterium animalis DN-173 010 in human feces during fermented milk administration. Collado M.C., Y. Moreno, J.M. Cobo, J.A. Mateos, M. Hernandez. Food Research International, 2006; 39: 530-535.

2005

• The effect of fermented yogurt on the prevention of diarrhea in a healthy adult population. Pereg D, Kimhi O, Tirosh A, Orr N, Kayouf R, Lishner M. Am J Infect Control. 2005 Mar;33(2):122-5.


• Effects of a specially designed fermented milk product containing probiotic Lactobacillus casei DN-114 001 and the eradication of H. pylori in children: a prospective randomized double-blind study. Sýkora J, Valecková K, Amlerová J, Siala K, Dedek P, Watkins S, Varvarovská J, Stozický F, Pazdiora P, Schwarz J. J Clin Gastroenterol. 2005 Sep;39(8):692-8.

2004

• The effect of milk fermented by yogurt cultures plus Lactobacillus casei DN-114001 on the immune response of subjects under academic examination stress. Marcos A, Wärnberg J, Nova E, Gómez S, Alvarez A, Alvarez R, Mateos JA, Cobo JM. Eur J Nutr. 2004 Dec;43(6):381-9.


• Daily ingestion of fermented milk containing Lactobacillus casei DN114001 improves innate-defense capacity in healthy middle-aged people. Parra MD, Martínez de Morentin BE, Cobo JM, Mateos A, Martínez JA. J Physiol Biochem. 2004 Jun;60(2):85-91.
  Monocyte function in healthy middle-aged people receiving fermented milk containing Lactobacillus casei. Parra D, De Morentin BM, Cobo JM, Mateos A, Martinez JA. J Nutr Health Aging. 2004;8(4):208-11.

2003

• Effect of fermented milk containing the probiotic Lactobacillus casei DN-114001 on winter infections in free-living elderly subjects: a randomised, controlled pilot study. Turchet P, Laurenzano M, Auboiron S, Antoine JM. J Nutr Health Aging. 2003;7(2):75-7.


• Recent advances in the use of functional foods: effects of the commercial fermented milk with Bifidobacterium animalis strain DN-173 010 and yoghurt strains on gut transit time in the elderly. Méance S, Cayuela C, Raimondi A, Turchet P, Lucas C and Antoine JM. Microbial Ecology in Health and Disease 2003; 15: 15-22.

2002

• Feasibility studies to control acute diarrhoea in children by feeding fermented milk preparations Actimel and Indian Dahi. Agarwal KN, Bhasin SK. Eur J Clin Nutr. 2002 Dec;56 Suppl 4:S56-9.


• Bifidobacterium animalis strain DN-173 010 shortens the colonic transit time in healthy women : a double blind, randomized, controlled study. Marteau P, Cuillerier E, Méance S, Gerhardt MF, Myara A, Bouvier M, Bouley C, Tondu F, Bommelaer G, Grimaud JC. Alimentary Pharmacology and Therapeutics, 2002; 16: 587-593.

2001

• Lactobacillus casei in the control of acute diarrhea--a pilot study. Agarwal KN, Bhasin SK, Faridi MM, Mathur M, Gupta S. Indian Pediatr. 2001 Aug;38(8):905-10.


• Effect of consumption of a milk fermented by the probiotic strain Bifidobacterium animalis DN-173 010 on colonic transit time in healthy humans. Bouvier M, Méance S, Bouley C, Berta JL and Grimaud JC. Bioscience Microflora. 2001; 20 (2): 43-48.


• A fermented milk with a Bifidobacterium probiotic strain DN-173 010 shortened oro-fecal gut transit time in elderly. Méance S, Cayuela C, Turchet P, Raimondi A, Lucas C and Antoine JM. Microbial Ecology in Health and Disease. 2001; 13: 217-222.

2000

• Multicentric study of the effect of milk fermented by Lactobacillus casei on the incidence of dia. Pedone CA, Arnaud CC, Postaire ER, Bouley CF, Reinert P. Int J Clin Pract. 2000 Nov;54(9):568-71.


• The effect of fermented milk containing Lactobacillus casei on the immune response to exercise. Pujol P, Huguet J, Drobnic F, Banquells M, Ruiz O, Galilea P, Segarra N, Aguilera S, Burnat A, Mateos JA, Postaire ER. Sports Med, Training and Rehab. 2000;9(3):209-223.


• A colony-immunoblotting method for quatitative detection of a Bifidobacterium animalis probiotic strain in human faeces. Duez H, Pelletier C, Cools S, Aissi E, Cayuela C, Gavini F, Bouquelet S, Neut C and Mengaud J. Journal of Applied Microbiology, 2000; 88:1019-27.

1999

• The effect of supplementation with milk fermented by Lactobacillus casei (strain DN-114 001) on acute diarrhoea in children attending day care centres. Pedone CA, Bernabeu AO, Postaire ER, Bouley CF, Reinert P. Int J Clin Pract. 1999 Apr-May;53(3):179-84.
  New insights in the validation of systemic biomarkers for the evaluation of the immunoregulatory properties of milk fermented with yogurt culture and Lactobacillus casei (Actimel ®): A prospective trial. Yoon H, Dubarry M, Bouley C, Meredith C, Portier A, Tome D, Renevot O, Blachon JL, Dugas B, Drewitt P, Postaire E. Int J Immunotherapy. 1999;15(2):79-89.

1998

• Milk fermented with yogurt cultures and Lactobacillus casei compared with yogurt and gelled milk: influence on intestinal microflora in healthy infants. Guerin-Danan C, Chabanet C, Pedone C, Popot F, Vaissade P, Bouley C, Szylit O, Andrieux C. Am J Clin Nutr. 1998 Jan;67(1):111-7.

1992

• Survival of Bifidobacteria ingested via fermented milk during their passage through the human small intestine: an in vivo study using intestinal perfusion. Pochart P, Marteau P, Bouhnik Y, Goderet I, Bourlioux P, Rambaud JC. American Journal of Clinical Nutrition, 1992; 55:78-80.

1991

• Bifidobacterium from fermented milks: Survival during gastric transit. Berrada N, Lemeland JF, Laroche G, Thouvenot P, Piaia M. Journal of Dairy Science, 1991; 74:409-413.

1990

• Isolement des bifidobactéries dans les selles après ingestion prolongée de lait au bifidus (LB). Pochart P, Marteau P, Bisetti N, Goderet I, Bourlioux P, Rambaud JC. No abstract available. Médecine et Maladies Infectieuses 1990; 20: 75-78 (publication in French).

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